在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human NEDD4 family-interacting protein 2 (NDFIP2), partial

  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-YP885735HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-EP885735HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-EP885735HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-BP885735HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NDFIP2重組蛋白
  • 貨號:
    CSB-MP885735HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    NDFIP2; KIAA1165; N4WBP5A; NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation. May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination.
  • 基因功能參考文獻:
    1. Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi. PMID: 26363003
    2. PTEN/Akt and MAP kinase signaling pathways are regulated by the ubiquitin ligase activators Ndfip1 and Ndfip2 PMID: 20534535
    3. role in regulating epithelial sodium channel PMID: 12050153
    4. N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes PMID: 12796489
    5. N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery PMID: 15252135
    6. Data show that the small PY-containing membrane proteins, NDFIP1 and NDFIP2 (NEDD4 family-interacting proteins), activate the catalytic activity of ITCH and of several other HECT ligases by binding to them. PMID: 19343052

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Endosome, multivesicular body membrane.
  • 組織特異性:
    Expressed in brain, lung, heart, skeletal muscle, kidney, liver and placenta.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 18537

    OMIM: 610041

    KEGG: hsa:54602

    STRING: 9606.ENSP00000218652

    UniGene: Hs.525093



主站蜘蛛池模板: 女人和拘做受全程看视频| а√资源新版在线天堂 | 日本一卡二卡不卡视频查询| 日韩人妻无码制服丝袜视频| 亚洲色一色噜一噜噜噜| 国产中的精品av一区二区| 亚洲性猛交xxxx| 老熟妇高潮一区二区三区| 九九精品成人免费国产片| 性中国妓女毛茸茸视频| 亚洲中文字幕无码乱线| 少妇人妻偷人精品视蜜桃| 亚洲性无码av中文字幕| 成年网站未满十八禁视频天堂| 色琪琪丁香婷婷综合久久| 伊人久久大香线蕉综合75| 国产最新进精品视频| 日本高清www午色夜在线视频| 国产成人无码激情视频| 欧美熟妇性xxx交潮喷| 精品欧洲av无码一区二区三区| 精品无码欧美黑人又粗又| 亚洲国产一区二区精品无码| 国产在线永久视频| 国产乱妇乱子视频在播放| 亚洲欧洲日产国码中文字幕| 国产传媒精品1区2区3区| 久久婷婷国产综合精品| 色五月五月丁香亚洲综合网| 久久亚洲精品中文字幕一区| 50岁熟妇的呻吟声对白| 成人h动漫精品一区二区无码| 老熟妻内射精品一区| 国产亚洲999精品aa片在线爽| 国产午夜福利久久精品| 久久无码av三级| 国产女人高潮抽搐叫床视频| 狠狠色丁香久久综合婷婷| 五月丁香六月综合av| 亚洲精品一区二区三区婷婷月| 双乳被一左一右吃着动态图|